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1

Structure–activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities

Ai-Lin Liu, Hai-Di Wang, Simon MingYuen Lee, Yi-Tao Wang, Guan-Hua Du

Journal:

Bioorganic & Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 191 KB

english, 2008

2

Anti-Influenza Virus Activities of Flavonoids from the Medicinal Plant Elsholtzia rugulosa

Liu, Ai-Lin, Liu, Bo, Qin, Hai-Lin, Lee, Simon, Wang, Yi-Tao, Du, Guan-Hua

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 135 KB

english, 2008

3

Novel Alkaloids from the Roots of Stemona sessilifolia

Peng Wang, Ai-Lin Liu, Zheng An, Zhi-Hong Li, Guan-Hua Du, Hai-Lin Qin

Journal:

Chemistry & Biodiversity

Année:

2007

Langue:

english

Fichier:

PDF, 103 KB

english, 2007

4

Predictions of BuChE Inhibitors Using Support Vector Machine and Naive Bayesian Classification Techniques in Drug Discovery

Fang, Jiansong, Yang, Ranyao, Gao, Li, Zhou, Dan, Yang, Shengqian, Liu, Ai-lin, Du, Guan-hua

Journal:

Journal of Chemical Information and Modeling

Année:

2013

Langue:

english

Fichier:

PDF, 1.65 MB

english, 2013

5

New Stemona alkaloids from the roots of Stemona tuberosa

Yue, Yong, Deng, An-Jun, Li, Zhi-Hong, Liu, Ai-Lin, Ma, Lin, Zhang, Zhi-Hui, Wang, Xiu-Li, Du, Gu-Hua, Qin, Hai-Lin

Journal:

Magnetic Resonance in Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 780 KB

english, 2014

6

Discovery of neuroprotective compounds by machine learning approaches

Fang, Jiansong, Pang, Xiaocong, Yan, Rong, Lian, Wenwen, Li, Chao, Wang, Qi, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 1.81 MB

english, 2016

7

Evaluation of Novel Dual Acetyl- and Butyrylcholinesterase Inhibitors as Potential Anti-Alzheimer’s Disease Agents Using Pharmacophore, 3D-QSAR, and Molecular Docking Approaches

Pang, Xiaocong, Fu, Hui, Yang, Shilun, Wang, Lin, Liu, Ai-Lin, Wu, Song, Du, Guan-Hua

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 9.40 MB

english, 2017

8

Integration of virtual screening with high-throughput screening for the identification of novel Rho-kinase I inhibitors

Li-Li Gong, Lian-Hua Fang, Jian-Hao Peng, Ai-Lin Liu, Guan-Hua Du

Journal:

Journal of Biotechnology

Année:

2010

Langue:

english

Fichier:

PDF, 1.02 MB

english, 2010

9

The self-assembly of catenated calix[4]arenes

Zhan-Ting Li, Guo-Zhen Ji, Shen-Dong Yuan, Ai-Lin Du, Hui Ding, Ming Wei

Journal:

Tetrahedron Letters

Année:

1998

Langue:

english

Fichier:

PDF, 220 KB

english, 1998

10

In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: Identifying sinensetin as a novel antiangiogenesis agent

In Kei Lam, Deepa Alex, You-Hua Wang, Ping Liu, Ai-Lin Liu, Guan-Hua Du, Simon Ming Yuen Lee

Journal:

Molecular Nutrition & Food Research

Année:

2012

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2012

11

3D QSAR and docking study of flavone derivatives as potent inhibitors of influenza H1N1 virus neuraminidase

Li Gao, Mian Zu, Song Wu, Ai-Lin Liu, Guan-Hua Du

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 2.20 MB

english, 2011

12

Chemical constituents of the whole plant of Elsholtzia rugulosa

Liu, Bo, Deng, An-Jun, Yu, Jin-Qian, Liu, Ai-Lin, Du, Guan-Hua, Qin, Hai-Lin

Journal:

Journal of Asian Natural Products Research

Année:

2012

Langue:

english

Fichier:

PDF, 156 KB

english, 2012

13

Self-Assembling Calix[4]arene [2]Catenanes. Preorganization, Conformation, Selectivity, and Efficiency

Li, Zhan-Ting, Ji, Guo-Zhen, Zhao, Cheng-Xue, Yuan, Shen-Dong, Ding, Hui, Huang, Chen, Du, Ai-Lin, Wei, Ming

Journal:

Journal of Organic Chemistry

Année:

1999

Langue:

english

Fichier:

PDF, 336 KB

english, 1999

14

In silico Target Fishing for the Potential Targets and Molecular Mechanisms of Baicalein as an Antiparkinsonian Agent: Discovery of the Protective Effects on NMDA Receptor-Mediated Neurotoxicity

Gao, Li, Fang, Jian-Song, Bai, Xiao-Yu, Zhou, Dan, Wang, Yi-Tao, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Chemical Biology & Drug Design

Année:

2013

Langue:

english

Fichier:

PDF, 1.69 MB

english, 2013

15

In vitro Antiviral Effects and 3D QSAR Study of Resveratrol Derivatives as Potent Inhibitors of Influenza H1N1 Neuraminidase

Li, Chao, Fang, Jian-Song, Lian, Wen-Wen, Pang, Xiao-Cong, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Chemical Biology & Drug Design

Année:

2015

Langue:

english

Fichier:

PDF, 1.21 MB

english, 2015

16

Consensus models for CDK5 inhibitors in silico and their application to inhibitor discovery

Fang, Jiansong, Yang, Ranyao, Gao, Li, Yang, Shengqian, Pang, Xiaocong, Li, Chao, He, Yangyang, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Molecular Diversity

Année:

2015

Langue:

english

Fichier:

PDF, 1.27 MB

english, 2015

17

Inhibition of acetylcholinesterase by two genistein derivatives: kinetic analysis, molecular docking and molecular dynamics simulation

Fang, Jiansong, Wu, Ping, Yang, Ranyao, Gao, Li, Li, Chao, Wang, Dongmei, Wu, Song, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Acta Pharmaceutica Sinica B

Année:

2014

Langue:

english

Fichier:

PDF, 1.67 MB

english, 2014

18

Discovery of Multitarget-Directed Ligands against Alzheimer’s Disease through Systematic Prediction of Chemical–Protein Interactions

Fang, Jiansong, Li, Yongjie, Liu, Rui, Pang, Xiaocong, Li, Chao, Yang, Ranyao, He, Yangyang, Lian, Wenwen, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Journal of Chemical Information and Modeling

Année:

2015

Langue:

english

Fichier:

PDF, 2.25 MB

english, 2015

19

Discovery of the neuroprotective effects of alvespimycin by computational prioritization of potential anti-parkinson agents

Gao, Li, Zhao, Gang, Fang, Jian-Song, Yuan, Tian-Yi, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 556 KB

english, 2014

20

Overexpression of miR-223 correlates with tumor metastasis and poor prognosis in patients with colorectal cancer

Li, Ze-wu, Yang, Yong-mei, Du, Lu-tao, Dong, Zhaogang, Wang, Li-li, Zhang, Xin, Zhou, Xuan-jun, Zheng, Gui-xi, Qu, Ai-lin, Wang, Chuan-xin

Journal:

Medical Oncology

Année:

2014

Langue:

english

Fichier:

PDF, 282 KB

english, 2014

21

Ameliorative effects of baicalein in MPTP-induced mouse model of Parkinson's disease: A microarray study

Gao, Li, Li, Chao, Yang, Ran-Yao, Lian, Wen-Wen, Fang, Jian-Song, Pang, Xiao-Cong, Qin, Xue-Mei, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Pharmacology Biochemistry and Behavior

Année:

2015

Langue:

english

Fichier:

PDF, 1.09 MB

english, 2015

22

Demonstration of Tightly Radiation-Controlled Molecular Switch Based on CArG Repeats byIn VivoMolecular Imaging

Hsieh, Ya-Ju, Hwu, Luen, Ke, Chien-Chih, Huang, Ai-Lin, Chen, Fu-Du, Wu, Shyh-Jong, Chen, Sharon Chia-Ju, Zhao, Yong-Hua, Liu, Ren-Shyan

Journal:

Molecular Imaging and Biology

Année:

2015

Langue:

english

Fichier:

PDF, 1.61 MB

english, 2015

23

Stemoninine-type alkaloids from the roots of Stemona sessilifolia

Wang, Peng, Liu, Ai-Lin, Li, Zhi-Hong, Du, Guan-Hua, Qin, Hai-Lin

Journal:

Journal of Asian Natural Products Research

Année:

2008

Langue:

english

Fichier:

PDF, 125 KB

english, 2008

24

In vitro Anti-Influenza Viral Activities of Constituents from Caesalpinia sappan

Liu, Ai-Lin, Shu, Shi-Hui, Qin, Hai-Lin, Lee, Simon, Wang, Yi-Tao, Du, Guan-Hua

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 118 KB

english, 2009

25

In Vitro Anti-influenza Viral Activities of Stilbenoids from the Lianas of Gnetum pendulum

Liu, Ai-Lin, Yang, Fan, Zhu, Mian, Zhou, Dan, Lin, Mao, Lee, Simon, Wang, Yi-Tao, Du, Guan-Hua

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 90 KB

english, 2010

26

DL0410 can reverse cognitive impairment, synaptic loss and reduce plaque load in APP/PS1 transgenic mice

Yang, Ran-Yao, Zhao, Gang, Wang, Dong-Mei, Pang, Xiao-Cong, Wang, Shou-Bao, Fang, Jian-Song, Li, Chao, Liu, Ai-Lin, Wu, Song, Du, Guan-Hua

Journal:

Pharmacology Biochemistry and Behavior

Année:

2015

Langue:

english

Fichier:

PDF, 3.39 MB

english, 2015

27

Discovery of Influenza A virus neuraminidase inhibitors using support vector machine and Naïve Bayesian models

Lian, Wenwen, Fang, Jiansong, Li, Chao, Pang, Xiaocong, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Molecular Diversity

Année:

2016

Langue:

english

Fichier:

PDF, 1.19 MB

english, 2016

28

Molecular Modeling on Berberine Derivatives toward BuChE: An Integrated Study with Quantitative Structure-Activity Relationships Models, Molecular Docking, and Molecular Dynamics Simulations

Fang, Jiansong, Pang, Xiaocong, Wu, Ping, Yan, Rong, Gao, Li, Li, Chao, Lian, Wenwen, Wang, Qi, Liu, Ai-lin, Du, Guan-hua

Journal:

Chemical Biology & Drug Design

Année:

2016

Langue:

english

Fichier:

PDF, 2.40 MB

english, 2016

29

DL0410, a novel dual cholinesterase inhibitor, protects mouse brains against Aβ-induced neuronal damage via the Akt/JNK signaling pathway

Zhou, Dan, Zhou, Wei, Song, Jun-ke, Feng, Zhang-ying, Yang, Ran-yao, Wu, Song, Wang, Lin, Liu, Ai-lin, Du, Guan-hua

Journal:

Acta Pharmacologica Sinica

Année:

2016

Langue:

english

Fichier:

PDF, 14.08 MB

english, 2016

30

A Novel Epitope from CD22 Regulates Th1 and Th17 Cell Function in Systemic Lupus Erythematosus

Yuan, Jing, Yu, Miao, Cao, Ai-Lin, Chen, Xiao, Zhang, Li-Hua, Song, You, Cheng, Xiang, Zhou, Zi-Hua, Wang, Min, Guo, He-Ping, Du, Rong, Liao, Yu-Hua, Zheng, Song Guo

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 3.76 MB

english, 2013

31

Actinomycin D synergistically enhances the cytotoxicity of CDDP on KB cells by activating P53 via decreasing P53–MDM2 complex

Wang, Lin, Pang, Xiao-Cong, Yu, Zi-Ru, Yang, Sheng-Qian, Liu, Ai-Lin, Wang, Jin-Hua, Du, Guan-Hua

Journal:

Journal of Asian Natural Products Research

Année:

2017

Langue:

english

Fichier:

PDF, 2.38 MB

english, 2017

32

Arginine vasopressin relates with spatial learning and memory in a mouse model of spinocerebellar ataxia type 3

Jiang, Hong-Bo, Du, Ai-Lin, Luo, Hai-Yang, Yang, Jun, Luo, Xiao-Qiu, Ma, Rui-Qing, Shi, Chang-He, Xu, Yu-Ming

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 997 KB

english, 2017

33

Network pharmacology-based analysis of Chinese herbal Naodesheng formula for application to Alzheimer's disease

PANG, Xiao-Cong, KANG, De, FANG, Jian-Song, ZHAO, Ying, XU, Lv-Jie, LIAN, Wen-Wen, LIU, Ai-Lin, DU, Guan-Hua

Journal:

Chinese Journal of Natural Medicines (Imprint ELSEVIER)

Année:

2018

Langue:

english

Fichier:

PDF, 2.17 MB

english, 2018

34

Discovery of VEGFR2 inhibitors by integrating naïve Bayesian classification, molecular docking and drug screening approaches

Kang, De, Pang, Xiaocong, Lian, Wenwen, Xu, Lvjie, Wang, Jinhua, Jia, Hao, Zhang, Baoyue, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 1.13 MB

english, 2018

35

Anti-influenza effect and action mechanisms of the chemical constituent gallocatechin-7-gallate from Pithecellobium clypearia Benth

Li, Chao, Xu, Lv-jie, Lian, Wen-wen, Pang, Xiao-cong, Jia, Hao, Liu, Ai-lin, Du, Guan-hua

Journal:

Acta Pharmacologica Sinica

Année:

2018

Langue:

english

Fichier:

PDF, 4.63 MB

english, 2018

36

The Bioinformatic Analysis of the Dysregulated Genes and MicroRNAs in Entorhinal Cortex, Hippocampus, and Blood for Alzheimer’s Disease

Pang, Xiaocong, Zhao, Ying, Wang, Jinhua, Zhou, Qimeng, Xu, Lvjie, Kang, De, Liu, Ai-Lin, Du, Guan-Hua

Journal:

BioMed Research International

Année:

2017

Langue:

english

Fichier:

PDF, 4.27 MB

english, 2017

37

Identification of Estrogen Receptor α Antagonists from Natural Products via In Vitro and In Silico Approaches

Pang, Xiaocong, Fu, Weiqi, Wang, Jinhua, Kang, De, Xu, Lvjie, Zhao, Ying, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Oxidative Medicine & Cellular Longevity

Année:

2018

Langue:

english

Fichier:

PDF, 9.27 MB

english, 2018

38

Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa

Zhang, Li, Cheng, Yong-Xian, Liu, Ai-Lin, Wang, Hai-Di, Wang, Ya-Ling, Du, Guan-Hua

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 286 KB

english, 2010

39

Drug Discovery of Host CLK1 Inhibitors for Influenza Treatment

Zu, Mian, Li, Chao, Fang, Jian-Song, Lian, Wen-Wen, Liu, Ai-Lin, Zheng, Li-Shu, Du, Guan-Hua

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 3.20 MB

english, 2015

40

DL0410 Ameliorates Memory and Cognitive Impairments Induced by Scopolamine via Increasing Cholinergic Neurotransmission in Mice

Lian, Wenwen, Fang, Jiansong, Xu, Lvjie, Zhou, Wei, Kang, De, Xiong, Wandi, Jia, Hao, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 3.22 MB

english, 2017

41

Design, Synthesis, and Biological Evaluation of a New Series of Biphenyl/Bibenzyl Derivatives Functioning as Dual Inhibitors of Acetylcholinesterase and Butyrylcholinesterase

Wang, Dong-mei, Feng, Bo, Fu, Hui, Liu, Ai-lin, Wang, Lin, Du, Guan-hua, Wu, Song

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 5.34 MB

english, 2017

42

Effects of P-Glycoprotein on the Transport of DL0410, a Potential Multifunctional Anti-Alzheimer Agent

Pang, Xiaocong, Wang, Lin, Kang, De, Zhao, Ying, Wu, Song, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 5.50 MB

english, 2017

43

Direct observation of broadband nonclassical states in a room-temperature light–matter interface

Dou, Jian-Peng, Yang, Ai-Lin, Du, Mu-Yan, Lao, Di, Li, Hang, Pang, Xiao-Ling, Gao, Jun, Qiao, Lu-Feng, Tang, Hao, Jin, Xian-Min

Journal:

npj Quantum Information

Année:

2018

Langue:

english

Fichier:

PDF, 1.07 MB

english, 2018

44

A broadband DLCZ quantum memory in room-temperature atoms

Dou, Jian-Peng, Yang, Ai-Lin, Du, Mu-Yan, Lao, Di, Gao, Jun, Qiao, Lu-Feng, Li, Hang, Pang, Xiao-Ling, Feng, Zhen, Tang, Hao, Jin, Xian-Min

Journal:

Communications Physics

Année:

2018

Langue:

english

Fichier:

PDF, 900 KB

english, 2018

45

Design, synthesis and biological evaluation of honokiol derivatives as influenza neuraminidase inhibitors

Lin, Ding, Yi, Yang-Jie, Xiao, Meng-Wu, Chen, Jia, Ye, Jiao, Hu, Ai-Xi, Lian, Wen-Wen, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Journal of Asian Natural Products Research

Année:

2018

Langue:

english

Fichier:

PDF, 1.73 MB

english, 2018

46

DL0410 ameliorates cognitive deficits in APP/PS1 transgenic mice by promoting synaptic transmission and reducing neuronal loss

Zhou, Wei, Lian, Wen-wen, Yan, Rong, Jia, Hao, Xu, Lv-jie, Wang, Lin, Liu, Ai-lin, Du, Guan-hua

Journal:

Acta Pharmacologica Sinica

Année:

2019

Langue:

english

Fichier:

PDF, 4.47 MB

english, 2019

47

DL0410 ameliorates cognitive deficits in APP/PS1 transgenic mice by promoting synaptic transmission and reducing neuronal loss

Zhou, Wei, Lian, Wen-wen, Yan, Rong, Jia, Hao, Xu, Lv-jie, Wang, Lin, Liu, Ai-lin, Du, Guan-hua

Journal:

Acta Pharmacologica Sinica

Année:

2019

Fichier:

PDF, 4.47 MB

2019

48

DL0410 ameliorates cognitive disorder in SAMP8 mice by promoting mitochondrial dynamics and the NMDAR-CREB-BDNF pathway

Lian, Wen-wen, Zhou, Wei, Zhang, Bao-yue, Jia, Hao, Xu, Lv-jie, Liu, Ai-lin, Du, Guan-hua

Journal:

Acta Pharmacologica Sinica

Année:

2020

Fichier:

PDF, 4.50 MB

2020